Leïla PERIÉ
Quantitative immune-hematology
Quantitative immune-hematology
KEYWORDS: Hematopoietic stem cells, Mouse, Human
Single cell differentiation, stem cell dynamics, differentiation tree
Single cell differentiation, stem cell dynamics, differentiation tree
|
UMR168
Institut Curie - Laboratoire Physico Chimie Curie Bâtiment Curie, RDC 11 rue Pierre et Marie Curie 75005 PARIS Webpage |
The immune system is composed of diverse, functionally distinct cell types that each contributes uniquely to immune responses. During adulthood, these diverse cell types originate from hematopoietic stem cells though a process called hematopoiesis. Our research interest lies in understanding quantitatively how this diversity is produced and maintained during homeostasis and infection. To tangle this question, we combine experimental and computational approaches of single cell analysis. In particular, we use a lineage tracing method called cellular barcoding that tracks the descendants of individual cells. In addition, our research aims at developing new lineage tracing methodologies to study hematopoiesis not only in mice but also in humans.
