Anne CAMUS
Stem cells and Axial Skeleton Development
Stem cells and Axial Skeleton Development
KEYWORDS: Notochordal cells
Cell fate control and differentiation, Morphogenesis, Gene network and Cell Signalling,
Homeostasis and Aging, Regeneration
Mouse embryo; human induced pluripotent stem cells
Cell fate control and differentiation, Morphogenesis, Gene network and Cell Signalling,
Homeostasis and Aging, Regeneration
Mouse embryo; human induced pluripotent stem cells
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Unité INSERM UMR 1229 / RMeS - Regenerative Medecine and Skeleton Faculté de Chirurgie Dentaire, 1 Place Alexis Ricordeau 44042 Nantes Cedex 01 Email A.Camus Webpage |
Our research focuses on basic cellular and molecular mechanisms that regulate cell fate choice and tissue patterning during embryogenesis and stem cell differentiation.
Our experimental approaches to study axial skeleton and intervertebral disc development combine (i) fundamental studies using mutant mouse models, (ii) innovative human stem cells differentiation systems making use of 3D scaffolds with tunable physico-chemical properties mimicking the native cell niche, and (iii) transcriptomic approach and imaging analysis at single-cell level.
Our major challenges are to decrypt the mechanisms and identify the actors involved in the differentiation of notochordal cells and intervertebral disc morphogenesis and to translate this fundamental understanding into inspiring future regenerative strategies.
Our experimental approaches to study axial skeleton and intervertebral disc development combine (i) fundamental studies using mutant mouse models, (ii) innovative human stem cells differentiation systems making use of 3D scaffolds with tunable physico-chemical properties mimicking the native cell niche, and (iii) transcriptomic approach and imaging analysis at single-cell level.
Our major challenges are to decrypt the mechanisms and identify the actors involved in the differentiation of notochordal cells and intervertebral disc morphogenesis and to translate this fundamental understanding into inspiring future regenerative strategies.
