Pascale DURBEC
Stem Cells and Brain Repair
Stem Cells and Brain Repair
KEYWORDS: Adult neural stem cells, Mouse, Regeneration
Our team study myelin regeneration rodent. This process has been observed in human, but this self-repair process is incomplete and insufficient. This regeneration is possible thanks to the presence in the brain of stem cells and progenitor cells that can replace oligodendrocytes the myelin forming cell. It is therefore important to understand all the mechanisms involved in the process of myelin repair in order to increase our knowledge on this process and develop new therapeutic strategies.
Our research aims to better understand the biology of adult progenitor and stem cells involved in remyelination. Our goal is to decipher the cellular and molecular mechanisms controlling the mobilization of these cells. We are trying to determine which cells are involved in the repair process. How these cells migrate to the lesion site? What are the factors that control their differentiation into oligodendrocytes in physiological and pathological conditions? We are looking for factors that can influence or control these events when administered to the animal. We use the mouse as a model organism and combine techniques of cell biology, molecular imaging and neurosurgery to answer these questions.
Recent publications:
1. Cayre M, Courtés S., Martineau F., Giordano M., Arnaud K. Zamaron A. and Durbec P. Netrin-1 contributes to vascular remodeling in SVZ and promotes progenitor emigration after demyelination. Development (2013) 140, 3107-3117.
2. Vernerey J., Macchi M., Magalon K., Cayre M, Durbec P. Ciliary Neurotrophic Factor controls progenitor migration during remyelination in the adult rodent brain. J Neurosci. (2013) Feb Vol. 33 (7) : 3240-3250.
3. Ferent J, Zimmer C, Durbec P, Ruat M, Traiffort E. Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination. J Neurosci. 2013 Jan 30;33(5):1759-72. PMID : 23365216
4. Magalon K., Zimmer C., Cayre M., Khaldi J., Bourbon C., Robles I., Tardif, G. , Viola A., Pruss R., Bordet T., and Durbec P. Olesoxime promotes oligodendrocyte maturation and myelin repair in rodent models of demyelinating disorders. Ann Neurol. 2012 Feb;71(2):213-26.
5. El Waly B, Macchi M, Cayre M, Durbec P. Oligodendrogenesis in the normal and pathological central nervous system. Front Neurosci. 2014 Jun 12;8:145. Review.
Our research aims to better understand the biology of adult progenitor and stem cells involved in remyelination. Our goal is to decipher the cellular and molecular mechanisms controlling the mobilization of these cells. We are trying to determine which cells are involved in the repair process. How these cells migrate to the lesion site? What are the factors that control their differentiation into oligodendrocytes in physiological and pathological conditions? We are looking for factors that can influence or control these events when administered to the animal. We use the mouse as a model organism and combine techniques of cell biology, molecular imaging and neurosurgery to answer these questions.
Recent publications:
1. Cayre M, Courtés S., Martineau F., Giordano M., Arnaud K. Zamaron A. and Durbec P. Netrin-1 contributes to vascular remodeling in SVZ and promotes progenitor emigration after demyelination. Development (2013) 140, 3107-3117.
2. Vernerey J., Macchi M., Magalon K., Cayre M, Durbec P. Ciliary Neurotrophic Factor controls progenitor migration during remyelination in the adult rodent brain. J Neurosci. (2013) Feb Vol. 33 (7) : 3240-3250.
3. Ferent J, Zimmer C, Durbec P, Ruat M, Traiffort E. Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination. J Neurosci. 2013 Jan 30;33(5):1759-72. PMID : 23365216
4. Magalon K., Zimmer C., Cayre M., Khaldi J., Bourbon C., Robles I., Tardif, G. , Viola A., Pruss R., Bordet T., and Durbec P. Olesoxime promotes oligodendrocyte maturation and myelin repair in rodent models of demyelinating disorders. Ann Neurol. 2012 Feb;71(2):213-26.
5. El Waly B, Macchi M, Cayre M, Durbec P. Oligodendrogenesis in the normal and pathological central nervous system. Front Neurosci. 2014 Jun 12;8:145. Review.