Katie SAWAI
Modeling transformation and resistance in leukemia
Modeling transformation and resistance in leukemia
KEYWORDS: Hematopoietic stem cells
Differentiation, hematopoiesis, aging, myeloid leukemia
Transgenic mice
Differentiation, hematopoiesis, aging, myeloid leukemia
Transgenic mice
The hematopoietic system consists of a variety of functionally distinct cell types that perform essential functions such as transport of nutrients and waste from tissues, wound healing, as well as immune responses. The continuous production of these diverse cells in sufficient numbers (known as hematopoiesis) is maintained by hematopoietic stem cells.
The Sawai team studies the functions of hematopoietic stem cells using a stem cell-specific lineage tracing system and single cell multiomic analyses. In particular, we aim to define the changes in hematopoietic stem cell and progenitor function during aging or myeloid leukemia and to identify the intracellular and extracellular factors that contribute to these alterations.
The Sawai team studies the functions of hematopoietic stem cells using a stem cell-specific lineage tracing system and single cell multiomic analyses. In particular, we aim to define the changes in hematopoietic stem cell and progenitor function during aging or myeloid leukemia and to identify the intracellular and extracellular factors that contribute to these alterations.
