Renata BASTO
Biology of Centrosomes, Chromosomes and Cell Division
Biology of Centrosomes, Chromosomes and Cell Division
KEYWORDS: Neural stem cells
Drosophila ; Adult and embryo mouse
Centrosomes, Microtubule cytoskeleton
Tissue architecture, proliferation, differentiation, apoptosis
Drosophila ; Adult and embryo mouse
Centrosomes, Microtubule cytoskeleton
Tissue architecture, proliferation, differentiation, apoptosis
The centrosome is the major microtubule (MT) organising center of animal cells. It consists of a pair of centrioles surrounded by a mesh of more than one hundred proteins, the pericentriolar material, which is the site of MT nucleation. Centrosomes play essential function sin spindle orientation, spindle assembly during mitosis or polarity establishment and as basal bodies for cilia assembly. Our lab is interested in characterising key molecular players in centrosome biogenesis and to understand how mutations in centrosome components impact on development and lead to the establishment of disease
Dapi/Tau/Cux1
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Drosophila brain with neural stem cells shown in green, differentiating cells in purple and dapi in blue
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