STEM CELLS IN VIVO (a French network)
  • About us
  • ABOUT STEM CELLS
  • RESEARCH MAPS
    • City map >
      • LYON
      • MARSEILLE
      • MONTPELLIER
      • NANTES
      • NICE
      • PARIS
      • STRASBOURG
      • TOULOUSE
      • VILLEFRANCHE-SUR-MER
    • Stem cells map
  • Teams
    • AVEROF
    • BALLYCUIF
    • BARDIN
    • BASTO
    • BRUNET
    • CROZATIER/VINCENT
    • CUMANO
    • DAVID
    • DAVY
    • DURBEC
    • FRE
    • GIANGRANDE
    • GOMEZ PERDIGUERO
    • HAENLIN/WALTZER
    • HASSAN
    • JAY
    • MAURANGE
    • PERIE
    • PERRON
    • PORTEU/SOLARY
    • RELAIX
    • ROMAGNOLO
    • ROTTINGER
    • SASSOON
    • SHKRELI
    • SPEDER
    • TAJBAKHSH
    • TIOZZO
  • News
  • Links
Béatrice ROMAGONOLO
Oncogenesis of digestive epithelia

KEYWORDS: ISC, mouse models, regeneration, cell differentiation, niche
Photo

Institut Cochin, Université Paris Descartes, CNRS UMR 8104, INSERM U1016, Department of Development, Reproduction and Cancer,
24 rue du Fb St Jacques
75014 Paris

Email
Webpage
The aim of our group is to understand the factors regulating the rapid turnover of the intestinal epithelium and their alteration in cancer. We are investigating known signaling pathways such as the Wnt/b-catenin pathway and search for critical downstream events as well as novel signalings that act as drivers for intestinal homeostasis and cancer. Our experimental approach relies on a combination of mouse genetics, biopsies of patients with colorectal cancer (CRC), molecular and cellular biology and analyses at the pan-genomic scale.

Our previous work has demonstrated that the Wnt/b-catenin signaling regulates multiple aspects of intestinal physiology, including cell proliferation and differentiation into the Paneth cell lineage. Paneth cells support intestinal stem cell by secreting Wnt ligands. However nonepithelial Wnt signals could provide a secondary physiological source of Wnt in case of Paneth cell ablation. Our result highlights a complex ISC niche. Our projects pursue the understanding of the factors required for the functional integrity of ISC by analyzing conditional knockout mutant mice and organoids culture.
Picture
Powered by Create your own unique website with customizable templates.
  • About us
  • ABOUT STEM CELLS
  • RESEARCH MAPS
    • City map >
      • LYON
      • MARSEILLE
      • MONTPELLIER
      • NANTES
      • NICE
      • PARIS
      • STRASBOURG
      • TOULOUSE
      • VILLEFRANCHE-SUR-MER
    • Stem cells map
  • Teams
    • AVEROF
    • BALLYCUIF
    • BARDIN
    • BASTO
    • BRUNET
    • CROZATIER/VINCENT
    • CUMANO
    • DAVID
    • DAVY
    • DURBEC
    • FRE
    • GIANGRANDE
    • GOMEZ PERDIGUERO
    • HAENLIN/WALTZER
    • HASSAN
    • JAY
    • MAURANGE
    • PERIE
    • PERRON
    • PORTEU/SOLARY
    • RELAIX
    • ROMAGNOLO
    • ROTTINGER
    • SASSOON
    • SHKRELI
    • SPEDER
    • TAJBAKHSH
    • TIOZZO
  • News
  • Links